Undifferentiated Uterine Sarcoma: Molecular Subtypes Found

Researchers at the Karolinska Institutet in Sweden have identified new molecular subtypes of undifferentiated uterine sarcoma, a rare type of cancer that is highly deadly and has no effective treatment options. "It is too early to propose a new treatment that will be useful for the patients today, but the study opens up new avenues for future research, which will create in time new treatment possibilities for women who suffer from these rare tumors," commented the study's senior author, Joseph C...
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Advanced Gynecologic Cancers: Olaparib Approved for Maintenance Therapy

The FDA has now approved olaparib (Lynparza®, AstraZeneca Pharmaceuticals LP) for maintenance treatment of adults with deleterious or suspected deleterious germline or somatic BRCA-mutated advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer experiencing complete or partial response to first-line platinum-based chemotherapy. Patients are to be selected for therapy using an FDA-approved companion diagnostic, the BRACAnalysis CDx® test (Myriad Genetic Laboratories, Inc.). The ...
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Epigenetic Cervical Cancer Test Yields 100% Detection Rate

Researchers recently developed a cervical screening exam that is able to accurately identify cervical cancer using epigenetics. At a fraction of the cost, this new epigenetic test outperformed Pap smears and human papillomavirus (HPV) exams in detecting cervical cancer by identifying naturally-occurring chemical markers that show up on top of the DNA, comprising its epigenetic profile. "This is an enormous development. We're not only astounded by how well this test detects cervical cancer, but i...
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HPV+ Without CIN: Still at Risk for Cervical Cancer

A cellular abnormality called cervical intraepithelial neoplasia (CIN) is a precursor for cervical cancer. However, scientists have now found that women who are positive for human papillomavirus (HPV) and negative for CIN are still at a very high risk for developing cervical cancer. In a study published in the journal Cancer , researchers identified 576 healthy women through the National Cervical Screening Registry who were screened between 2005 to 2007 and tested negative for CIN. During a foll...
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Communication Between Fallopian Tube and Ovary Influences Ovarian Cancer

Ovarian tumor microenvironment. Credit: NCI Researchers at the University of Illinois at Chicago have demonstrated that cancer cells present in the fallopian tube influence the chemical environment surrounding the ovary. It has been known for several years that communication between the tumor and normal cells dictates the process of tumor development. However, the relationship between tumor and normal cells has been poorly understood in high-grade serous ovarian cancer (HGSOC), since recent rese...
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