Therapeutic Target Found in MSI-High Tumors

​ Microsatellite instability (MSI), characteristic variations in the length of tandem nucleotide repeats across the genome, has been seen in a wide variety of cancers, including colon cancer, gastric cancer, endometrium cancer, ovarian cancer, hepatobiliary tract cancer, urinary tract cancer, brain cancer, and skin cancers. Researchers' discovery of the important role played by Werner syndrome helicase (WRN) in MSI-high (MSI-H) tumors presents a new opportunity for the development of targeted th...
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Overprescribing Preventive Drugs to Elderly Patients With Advanced Cancer

Researchers discovered that elderly patients with advanced cancer who continue to take some preventive drugs might not achieve clinical benefit during their remaining lifespan, thereby rendering the drugs unnecessary money and time wasters. In this study, published in Cancer, the investigators found that in 151,201 adults older than 65 with advanced cancer who passed away, patients were prescribed an average of 6.9 to 10.1 drugs over the last year of their life. Preventive drugs, such as antihyp...
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Could Cervical Cancer Be Eliminated Worldwide by 2099?

​ Cervical cancer is the fourth most common cancer in women, with approximately 570,000 cases diagnosed worldwide during the year 2018. Yet because this cancer most frequently results from specific strains of the human papillomavirus (HPV) for which a vaccine is now FDA-approved in individuals up to the age of 45 , it is becoming largely preventable. With this in mind, the World Health Organization called last year for the elimination of cervical cancer as a public health problem. A team of Aust...
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The Bacterial Microbiome Plays a Role in Cervical Cancer

Almost all (99%) of cervical cancers stem from certain strains of human papillomavirus (HPV) that cause precancerous lesions. In a recent study, scientists report that the cervical bacterial microbiome plays a crucial role in the development of HPV and, in turn, in the development of cervical cancer. In the study, which was published in mBio, the journal of the American Society for Microbiology, the investigators used cytobrush swabs to collect samples from cervical lesions from 144 Tanzanian wo...
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Undifferentiated Uterine Sarcoma: Molecular Subtypes Found

Researchers at the Karolinska Institutet in Sweden have identified new molecular subtypes of undifferentiated uterine sarcoma, a rare type of cancer that is highly deadly and has no effective treatment options. "It is too early to propose a new treatment that will be useful for the patients today, but the study opens up new avenues for future research, which will create in time new treatment possibilities for women who suffer from these rare tumors," commented the study's senior author, Joseph C...
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