HPV+ Without CIN: Still at Risk for Cervical Cancer

A cellular abnormality called cervical intraepithelial neoplasia (CIN) is a precursor for cervical cancer. However, scientists have now found that women who are positive for human papillomavirus (HPV) and negative for CIN are still at a very high risk for developing cervical cancer. In a study published in the journal Cancer , researchers identified 576 healthy women through the National Cervical Screening Registry who were screened between 2005 to 2007 and tested negative for CIN. During a foll...
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Communication Between Fallopian Tube and Ovary Influences Ovarian Cancer

Ovarian tumor microenvironment. Credit: NCI Researchers at the University of Illinois at Chicago have demonstrated that cancer cells present in the fallopian tube influence the chemical environment surrounding the ovary. It has been known for several years that communication between the tumor and normal cells dictates the process of tumor development. However, the relationship between tumor and normal cells has been poorly understood in high-grade serous ovarian cancer (HGSOC), since recent rese...
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HPV Vaccine Approval Expanded Through Age 45

​ In a step crucial to preventing the occurrence of both the human papillomavirus (HPV) and HPV-related cancers, the United States Food and Drug Administration (FDA) has expanded the approval of the 9-valent human papillomavirus (9vHPV) vaccine (Gardasil®9, Merck and Co.) for men and women between the ages of 27 and 45. The human papillomavirus infects approximately 14 million Americans each year. It is also a well-documented cause of a number of cancers, including cervical carcinoma and orophar...
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Reduced Risk of Ovarian Cancer With Low-Dose Aspirin Use

A new study conducted by Moffitt Cancer Center in conjunction with Huntsman Cancer Institute and Harvard T.H. Chan School of Public Health found that women who take low-dose aspirin daily are at lower risk of developing ovarian cancer. The findings, published online by JAMA Oncology, also show that women who take at least 10 tablets per week of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen over many years are at an increased risk of developing ovarian can...
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Ovarian Cancer: Researchers Predict PARP Inhibitor Response

​ Researchers have found a way to identify which patients with high-grade serous ovarian carcinoma (HGSOC), the most malignant and most common form of ovarian cancer, will respond to poly (ADP-ribose) polymerase (PARP) inhibitor therapy. The answer to this question, as addressed in a study published in Nature Communications , could allow doctors to tailor patients' therapy on an individual basis, facilitating better treatment responses and increased chances of survival. Mutations of two BRCA gen...
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