A Way to Avoid Glioblastoma Invasion

Researchers' discovery that forces enhancing fluid flow within a glioblastoma's interstitial spaces can increase the cancer's invasion of surrounding tissue has critical implications for a new drug delivery technique. However, the investigators have also found a solution to this problem. The most common form of brain cancer, glioblastoma is also the most malignant. Because it is characterized by invasion into the surrounding brain tissue, it is highly difficult to treat and invariably relapses. ...
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Implementing Molecular Profiling at Initial Diagnosis for Pediatric Brain Tumor Patients With James M. Olson, MD, PhD

James M. Olson, MD, PhD

​Brain and spinal cord tumors are the second most common cancers in children, accounting for 1 out of 4 childhood cancers. Despite intensive treatment, children with histologically diagnosed high-risk medulloblastoma, supratentorial primitive neuroectodermal tumor of the central nervous system (CNS-PNET), and pineoblastoma (PBL) continue to have suboptimal outcomes. James M. Olson, MD, PhD, Professor of Pediatric Hematology/Oncology at University of Washington School of Medicine, and colleagues found that molecular profiling of patients with CNS-PNET/PBL revealed a significant proportion of patients were initially misdiagnosed and consequently overtreated and that other patients have a better prognosis than previously realized. i3 Health spoke with Dr. Olson about these findings and their implications for pediatric brain tumor practice.

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Faulty DNA Repair in Medulloblastomas and High-Grade Gliomas

Researchers have found that medulloblastomas and high-grade gliomas, two types of brain tumors, often exhibit frequent, complex rearrangements of the genome as a result of malfunctioning DNA repair. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) investigated the cause of chromothripsis, one of two "catastrophic genomic events" that cause genomic instability and are implicated in the development of cancer. In chromothripsis, tens to hundreds of clustered ...
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Medulloblastoma: New Genetic Marker Differentiates Risk

Researchers have identified a new genetic marker that can be used to determine which patients with medulloblastoma have high-risk tumors in need of aggressive treatment. "Medulloblastoma is the most common malignant childhood brain tumor, and it is important that we have improved outcomes for patients with this disease," commented Steve Clifford, PhD, Director of the Northern Institute for Cancer Research at Newcastle University and co-senior author of the study, which was published in Lancet On...
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New Treatment Targets Chemotherapy-Resistant Brain Cancer

Researchers have demonstrated the efficacy of a new treatment targeting genetic mutations in patients with chemotherapy-resistant secondary glioblastoma (sGBM), a rare and deadly form of brain cancer. Low-grade gliomas progress into sGBM, which has limited treatment options and a 5-year survival rate under 10%. Secondary glioblastoma is treated with temozolomide (TMZ), a chemotherapy drug. Upon relapse, which happens in most patients, genetic mutations enable sGBM tumors to resist the drug's eff...
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