Using Surgical Smoke to Detect Brain Malignancies

Electrosurgical resection, a common neurosurgery technique done with an electric knife or diathermy blade, produces surgical smoke, called diathermy smoke, from the burning of tissue during the procedure. Researchers in Finland have developed a device that can identify cancerous brain tissue based on properties of the diathermy smoke. This device could enable a surgeon to more quickly and accurately identify malignant tissue during brain cancer surgery in order to ensure that all parts...
Continue reading

Tozuleristide Enables Fluorescence-Guided Surgery in Glioma

​ For patients with gliomas, tumors that begin in the glial cells of the brain and spinal cord, fluorescence-guided surgery (FGS) can improve the extent of surgical resection by enabling neurosurgeons to better see the margins of the malignancies that they are trying to remove. A recent study has revealed that when used with a new, high-sensitivity near-infrared camera, tozuleristide (BLZ-100) provides effective imaging for FGS in adults with newly diagnosed or recurrent gliomas. The high-sensit...
Continue reading

ALK2 Inhibitors: Hope for Incurable Childhood Glioma

​ Researchers have found two activin receptor-like kinase 2 (ALK2) inhibitors that show promise in treating preclinical models of ACVR1-mutant diffuse intrinsic pontine glioma (DIPG). An incurable childhood tumor of the brain stem, DIPG has a median overall survival of nine to 12 months. The chemotherapy treatments most commonly used in histologically similar tumors found in other areas of the brain do not work with DIPG; the only treatment that produces a response is radiotherapy. Within two ye...
Continue reading

Lifetime Brain Metastasis Risk in Older Patients With Cancer

Older adults with lung, breast, and skin cancers have an increased risk of developing brain metastasis during their lifetime. But how big is this risk? In an effort to find out, researchers used data from the Surveillance, Epidemiology, and End Results (SEER) Program on patients with lung cancer, breast cancer, or melanoma diagnosed with a brain metastasis, either one identified during primary cancer staging workup, called a synchronous brain metastasis (SBM), or one detected later in life, call...
Continue reading

CRISPR-Cas9 Technology Used to Understand Glioblastoma

The most common type of primary malignant brain tumor in adults, glioblastoma is also one of the deadliest cancers, with a median survival rate of 10 to 14 months. Until recently, understanding of glioblastoma growth and survival was limited. Now, scientists report that "reverse engineering" glioblastoma stem cells gene by gene using CRISPR-Cas9 unveiled multiple therapeutic targets to combat treatment resistance, including the SOX transcription factor family. "We think that, in one big experime...
Continue reading

© Copyright 2019 i3 Health. All rights reserved.