Luminal A Breast Cancer: Worse Outcome for Younger Patients

In a new study, investigators discovered that younger women diagnosed with breast cancer have poorer prognoses compared with their older counterparts. This link is specific to patients with hormone-receptor positive luminal A breast cancer, the most common subtype. The study classified patients diagnosed with invasive breast cancer into three groups according to age: 40 and under, 41 to 60, and over 60. In the 40 and under age group, patients with hormone-receptor positive luminal A breast cance...
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Breast Cancer-Associated Fibroblasts: All Are Not Equal

​ In breast cancer, pancreatic cancer, hepatic carcinoma, and a number of other malignancies, cancer-associated fibroblasts (CAFs) are the most prominent cell type within the tumor microenvironment. The fact that they assist the cancer's survival in many ways makes them candidates for targeted therapy. Although CAFs can be identified through their shape and structure, commonly used cellular biomarkers have not been shown to feature in all of them. This fact has raised an important question: are ...
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Accelerated Aging Linked to Breast Cancer Treatments

Cancer treatments such as chemotherapy and radiation work by damaging the DNA of cancer cells, thereby killing them. Unfortunately, it is impossible for these treatments to target only the diseased cells; therefore, surrounding healthy cells also suffer from DNA damage as a result of treatment. This DNA damage to healthy cells could have dire consequences. Findings from a study published in Cancer reveal that certain treatments for breast cancer increase patients' exposure to toxicities that may...
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Migraine and Epilepsy Drug Inhibits Breast Tumor Growth

By screening existing Food and Drug Administration (FDA)-approved compounds, a research team has found that flunarizine, a drug previously approved for the treatment of migraines and epilepsy, can inhibit tumor growth in the highly aggressive breast cancer subtype known as basal-like breast cancer (BLBC). Basal-like breast cancer has a poor prognosis and lacks effective therapies. It typically does not express any of the three hormone receptors—estrogen receptor alpha, progesterone receptor, or ...
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Preventing Premature Menopause in Breast Cancer Chemotherapy

Chemotherapy can cure early-stage breast cancer, but it can also result in premature menopause, a highly unwelcome long-term side effect. In the final results of its investigation, the Southwest Oncology Group (SWOG)'s Prevention of Early Menopause Study (POEMS) reports a potential solution: women who receive goserelin (Zoladex®, AstraZeneca) along with standard chemotherapy for hormone-receptor negative breast cancer increase their chances of becoming pregnant without negatively impacting ...
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