New Biomarker Predicts Cancer Prognosis

Cancer diagnoses do not always come with a predictable future; sometimes, the impending course of the disease is uncertain. However, this terrifying unknown may soon be a thing of the past. When Jason Sheltzer, PhD, a Cold Spring Harbor Laboratory Fellow from Massachusetts Institute of Technology, and software engineer Joan Smith pored over the genomic profiles of 17,879 patients with cancer in search of common identifiable factors, they discovered a specific type of biomarker that can determine...
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Luminal A Breast Cancer: Worse Outcome for Younger Patients

In a new study, investigators discovered that younger women diagnosed with breast cancer have poorer prognoses compared with their older counterparts. This link is specific to patients with hormone-receptor positive luminal A breast cancer, the most common subtype. The study classified patients diagnosed with invasive breast cancer into three groups according to age: 40 and under, 41 to 60, and over 60. In the 40 and under age group, patients with hormone-receptor positive luminal A breast cance...
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Inflammatory Bowel Disease: Risk Factor for Prostate Cancer

In a recent study , inflammatory bowel disease (IBD) was found to be a potential precursor to prostate cancer. A twenty-year analysis of 1,033 men with IBD and 9,306 healthy men showed that those with IBD had a higher incidence rate of developing prostate cancer than those without IBD. IBD, which includes Crohn's disease and ulcerative colitis, is a common ailment in the US, afflicting approximately 1.6 million people, 1 million of them being men. The study, published in European Urology , found...
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Device Can Predict Propensity for Metastasis

Disease growth to distant tissues and organs is the leading cause of cancer-related death. Up until recently, there was only technology available to detect when cancer had already metastasized; however, scientists at University of California San Diego School of Medicine developed sensors that have the capability of detecting and measuring cancer's growth potential. "Cancer would not be so devastating if it did not metastasize. Although there are many ways to detect metastasis once it has occurre...
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Damaged DNA Linked Directly to Malignant Diseases

Mutagenesis is caused not only by errors in DNA doubling but also by DNA damage. Just how many mutations are caused by environmental factors as opposed to internal mistakes? Scientists have come close to uncovering the answer to that question in a study published in Nature Genetics. "We decided to look at this problem from a different perspective and evaluated the contribution of the DNA damage to the accumulation of mutations," explained the study's lead author, Vladimir Seplyarskiy, PhD, of th...
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