In Melanoma, Smoking Impacts Antitumor Immune Response

The immune system's response to melanoma both improves survival for untreated patients and predicts a patient's response to immune checkpoint blockade therapy. A British study has now identified several genetic factors that can be used to predict a patient's immune response to melanoma. The study has also identified a significant environmental cause of lowered antitumor immunity: cigarette smoking. For the study, published in Cancer Research , investigators used a bioinformatic analysis of 703 t...
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Like Smoking, Vaping Creates Cancer-Causing Changes

The last few years have seen a nearly 10-fold increase in electronic cigarette (e-cig) use, or "vaping," particularly among adult smokers and among adolescents who have never smoked a cigarette. E-cigs are frequently touted as a safer alternative to traditional cigarettes, but new research done at the University of Southern California (USC) reveals that vaping produces some of the same cancer-causing molecular changes to oral tissue that are produced by cigarette smoking. "The existing data show...
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New Multi-Tumor Syndrome Identified

​ Researchers have now discovered that a set of mutations known to play a role in colorectal cancer predisposes individuals to a multi-tumor syndrome that increases risk for breast cancer and other cancers. "We presumed to know all multi-tumor syndromes, but we have taken yet another step in identifying cancer genes," stated Nicoline Hoogerbrugge, MD, PhD, Professor of Hereditary Cancer at Radboud University Medical Center and one of the authors of the study, which was published in Cancer Cell ....
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How to Help Cancer Patients Quit Smoking

​ After a cancer diagnosis, nearly half of patients who smoke continue to do so, even though continued smoking can negatively impact the outcome of their disease. A team of researchers from Northwestern University's Feinberg School of Medicine and the University of Pennsylvania's Abramson Cancer Center has found that lengthening patients' use of an anti-smoking medication can lead to better smoking cessation outcomes for those who adhere to the treatment. "With the stress cancer patients are und...
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CK2 Inhibitor Disrupts Cancer’s Circadian Rhythm

Circadian rhythm is an important internal biological clock in charge of daily physiological processes. It regulates the sleep/wake cycle, body temperature, hormone secretion, and energy metabolism. Cells in the human body are dictated by their own circadian rhythm. According to a new study published in Science Advances , manipulating cancerous cells' circadian rhythm could potentially harm or kill malignancies by stunting their growth. In this study, researchers from the University of Southern C...
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