Therapeutic Target Identified in Chemo Brain

Chemotherapy is a life-saving treatment for many patients with cancer. However, it can also leave patients with lasting neurological deficits through a condition commonly known as "chemo brain." "It's wonderful that they're alive, but their quality of life is really suffering," commented Erin Gibson, PhD, a postdoctoral researcher at the Stanford University School of Medicine. "If we can do anything to improve that, there is a huge population that could benefit." In a study published in Cell , D...
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Preventing Premature Menopause in Breast Cancer Chemotherapy

Chemotherapy can cure early-stage breast cancer, but it can also result in premature menopause, a highly unwelcome long-term side effect. In the final results of its investigation, the Southwest Oncology Group (SWOG)'s Prevention of Early Menopause Study (POEMS) reports a potential solution: women who receive goserelin (Zoladex®, AstraZeneca) along with standard chemotherapy for hormone-receptor negative breast cancer increase their chances of becoming pregnant without negatively impacting ...
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Expanding Breast Cancer Surveillance in Survivors of Childhood Cancer

A new study published in Clinical Cancer Research and spearheaded by Zhaoming Wang, PhD, Associate Member of the Department of Epidemiology and Cancer Control at St. Jude Children's Research Hospital in Memphis, demonstrates that female childhood cancer survivors are at an increased risk of developing breast cancer later in life. Dr. Wang found that chest irradiation and exposure to high-dose chemotherapeutic agents used to treat childhood cancer added to future breast cancer susceptibility. The...
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Nanoparticles Enhance Chemotherapy Response

By combining tumor-modulating nanoparticles with chemotherapy regimens such as doxorubicin, scientists at the University of Toronto's Leslie Dan Faculty of Pharmacy have found a method to enhance chemotherapeutic efficacy and boost antitumor immunity. The researchers introduced hybrid polymer-lipid encapsulated manganese dioxide nanoparticles (PLMD NP) in breast cancer mouse models. These nanoparticles function by accumulating in the tumor and remodeling the tumor environment by generating oxyge...
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Complementary Medicine Reduces Cancer Treatment Side Effects

The field known as integrative oncology involves a combination of conventional antitumor therapies and complementary therapies used to enhance wellness, improve quality of life, and relieve disease symptoms and treatment side effects. A study published this week in The Journal of Alternative and Complementary Medicine found that integrative oncology facilitated adherence to conventional cancer treatment and reduced treatment-related adverse effects. The study, by Elio Rossi, MD and colleagues at...
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