Could Strawberry Tree Honey Fight Colon Cancer?

Researchers report that strawberry tree honey, a typical food in the Mediterranean region, has cancer-fighting potential in colon adenocarcinoma, the most common form of colorectal cancer. For the study, which has now been published in the Journal of Functional Foods , the investigators researched both the phytochemical composition and the anticancer effects of honey from the strawberry tree ( Arbutus unedo ) on cellular proliferation, cell cycle, and apoptosis—programmed cell death—in two types...
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Colorectal Cancer: MEK Inhibitors Promote Resistance

Forty-five percent of colorectal cancers are driven by mutations causing overactivation of the Ras signaling pathway. MEK inhibitors mitigate this overactivation, so why are they ineffective in the treatment of colorectal cancer? Researchers at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now found a possible explanation: in colorectal cancer, MEK inhibitors activate signaling of the Wnt pathway, thereby causing stem c...
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Should Patients Take Aspirin Before Colorectal Screening?

Fecal immunochemical tests measure the level of hemoglobin in a patient's blood in order to help determine if they may have colorectal cancer. Prior studies have suggested the possibility that a single dose of oral aspirin taken before the test may help fecal immunochemical tests to detect advanced colorectal neoplasms more effectively. To test this notion, researchers compared a group of patients who took aspirin before their test to a group of patients who took a placebo before their test and ...
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Ad5-GUCY2C-PADRE Colon Cancer Vaccine Effective in Humans

A phase I clinical trial reports that the cancer vaccine Ad5-GUCY2C-PADRE produces an immune response with minimal adverse events in patients with early-stage colorectal cancer. Colorectal cancer is the fourth most common cancer and the second leading cause of cancer death worldwide. Of the two-thirds of patients who undergo surgical resection with curative intent, 30% to 50% experience disease recurrence and die as a result of their cancer. Since adjuvant chemotherapy has no clinical benefit in...
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An Alternative to Biopsy: Improved CTC Collection Method

​ Researchers at the University of Michigan have developed a prototype of a wearable device that can continuously collect circulating tumor cells (CTCs) directly from a patient's bloodstream. The investigators hope that this device, which has thus far proven successful in canine models, could ultimately be used as an alternative to biopsies. Circulating tumor cells, which circulate through lymphatic channels and blood after they are shed from the primary tumor, are the basis for cancer metastase...
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