New Multi-Tumor Syndrome Identified

​ Researchers have now discovered that a set of mutations known to play a role in colorectal cancer predisposes individuals to a multi-tumor syndrome that increases risk for breast cancer and other cancers. "We presumed to know all multi-tumor syndromes, but we have taken yet another step in identifying cancer genes," stated Nicoline Hoogerbrugge, MD, PhD, Professor of Hereditary Cancer at Radboud University Medical Center and one of the authors of the study, which was published in Cancer Cell ....
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The Immune System Can Prevent Colon Cancer

Epithelial stem cell DNA damage can accumulate and turn into bowel cancer if it is not eradicated. Damaged cells can either be repaired, or, if the damage is too excessive, the cells can program their own death. Researchers have discovered that this repair mechanism is not only triggered by stem cells but also by the body's own immune system, thereby preventing colon cancer. In the study, published in Nature, the investigators discovered that the immune system is able to recognize glucosinolates...
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New Targets Identified in BRCA-Mutated Cancers

Researchers at Brigham and Women's Hospital have identified two new genes that can impact BRCA2-deficient cancer through "synthetic lethality," which occurs when a combination of deficiencies in two or more genes leads to cell death that would not occur with one deficiency alone. Inactivation of BRCA1 or BRCA2, both important tumor suppressor genes named for their roles in breast cancer, increases a woman's risk of breast cancer by up to 80% and increases her risk of ovarian cancer by around 50%...
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Fiber and Whole Grains Reduce Cancer, Cardiovascular Risks

​ Dietary fiber and whole grains are commonly thought to be good for our health. But do they truly have an impact on the risk of noncommunicable diseases, including cancer, heart disease, and other conditions? According to a new study published in The Lancet , the answer to that question is yes. "Previous reviews and meta-analyses have usually examined a single indicator of carbohydrate quality and a limited number of diseases, so it has not been possible to establish which foods to recommend fo...
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Long-Term Colon Cancer Risk Lower After Normal Colonoscopy

The guidelines regarding colon cancer recommend that average-risk patients undergo a colonoscopy every 10 years, even if their previous colonoscopy results were negative. However, until recently, there has been limited evidence to support this recommendation. To address this lack of evidence, investigators studied 1.25 million individuals aged 50 to 75 who were considered to have average risk for developing colon cancer. Average risk entails an absence of the following: a personal history of col...
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