An Alternative to Biopsy: Improved CTC Collection Method

​ Researchers at the University of Michigan have developed a prototype of a wearable device that can continuously collect circulating tumor cells (CTCs) directly from a patient's bloodstream. The investigators hope that this device, which has thus far proven successful in canine models, could ultimately be used as an alternative to biopsies. Circulating tumor cells, which circulate through lymphatic channels and blood after they are shed from the primary tumor, are the basis for cancer metastase...
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Therapeutic Target Found in MSI-High Tumors

​ Microsatellite instability (MSI), characteristic variations in the length of tandem nucleotide repeats across the genome, has been seen in a wide variety of cancers, including colon cancer, gastric cancer, endometrium cancer, ovarian cancer, hepatobiliary tract cancer, urinary tract cancer, brain cancer, and skin cancers. Researchers' discovery of the important role played by Werner syndrome helicase (WRN) in MSI-high (MSI-H) tumors presents a new opportunity for the development of targeted th...
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Opposite of Sweet: High-Fructose Corn Syrup Promotes Colon Cancer Growth

Researchers have discovered that two sweeteners used in soft drinks—high-fructose corn syrup and sucrose—encourage colon cancer growth in mice. For the experiment, results of which were published in Science , the investigators administered a daily dose of high-fructose corn syrup, an amount equivalent to one soda for humans, to mice who had been genetically engineered to develop colon cancer. A control group of mice, also genetically engineered to develop colon cancer, was not fed high-fructose ...
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Distinctive Features of Early-Onset Colorectal Cancer

In adults under the age of 50, colorectal cancer (CRC) diagnoses are increasing. Researchers from the University of Texas MD Anderson Cancer Center compared CRC features in patients younger than 50 to patients older than 50 and found that there were many differences between early-onset and traditional CRC. For this study, published in Cancer , the researchers analyzed 36,000 patients with CRC. They discovered that microsatellite instability, synchronous metastatic disease, primary tumors in the ...
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Compound Fights Colorectal Cancer Caused by High-Fat Diets

Colorectal cancer rates are increasing for individuals under the age of 55. The scientists at the Salk Institute for Biological Studies have discovered that diets high in fat, combined with dysregulated WNT signaling, which lead to imbalances in intestinal bile acids, are to blame for this increasing prevalence. They also revealed that a compound called FexD inhibits colorectal cancer cell growth caused by high-fat diets. "This study provides a new way to lower inflammation, restore intestinal h...
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