FDA Approves Erdafitinib for Metastatic Urothelial Carcinoma

Erdafitinib (Balversa™, Janssen Pharmaceutical Companies) was recently granted FDA approval for patients with locally advanced or metastatic urothelial carcinoma with susceptible FGFR3 or FGFR2 genetic alterations that has progressed during or following platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. Erdafitinib targets genetic alterations that occur in FGFRs, which regulate important biological processes, including cell g...
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FDA Expands Pembrolizumab Approval for NSCLC

Previously, pembrolizumab (Keytruda®, Merck Inc.) was approved as a single agent for first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1 with a tumor proportion score (TPS)  greater than or equal to 50%. The FDA has now expanded approval for first-line pembrolizumab to include patients with stage III NSCLC who do not qualify for surgical resection or definitive chemoradiation or metastatic NSCLC. For patients to qualify for tre...
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Metastatic Breast Cancer: Palbociclib Now Approved for Men

​ The FDA has now expanded the indication for palbociclib (Ibrance®, Pfizer Inc.) in combination with an aromatase inhibitor or fulvestrant (Faslodex®, AstraZeneca) to include men with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. Because breast cancer in men is rare, comprising less than 1% of all breast cancer cases, men with breast cancer are more likely to be diagnosed at an older age and with a more advanced st...
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Subcutaneous Trastuzumab in HER2-Positive Breast Cancer: An Interview with Constance Visovsky, PhD, RN, ACNP, FAAN

​ Recently, the FDA approved subcutaneous trastuzumab/hyaluronidase-oysk injection (Herceptin Hylecta TM , Genentech, Inc.) for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. In this interview with i3 Health, Constance Visovsky, PhD, RN, ACNP, FAAN, Associate Professor at the University of South Florida's College of Nursing, discusses the significance of this approval and shares advice for nurses treating patients with breast cancer. Can you comment on t...
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First-Line Atezolizumab Approved: Extensive-Stage SCLC

​ The FDA has approved atezolizumab (Tecentriq®, Genentech, Inc.) in combination with carboplatin and etoposide as first-line treatment for patients with extensive-stage (ES) small cell lung cancer (SCLC). This is the first immunotherapy-based combination to be approved in the initial treatment of ES-SCLC. Extensive-stage SCLC has spread widely throughout the lung, to the other lung, to lymph nodes on the other side of the chest, to the fluid around the lung, or to other areas in the body, such ...
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