Like Smoking, Vaping Creates Cancer-Causing Changes

The last few years have seen a nearly 10-fold increase in electronic cigarette (e-cig) use, or "vaping," particularly among adult smokers and among adolescents who have never smoked a cigarette. E-cigs are frequently touted as a safer alternative to traditional cigarettes, but new research done at the University of Southern California (USC) reveals that vaping produces some of the same cancer-causing molecular changes to oral tissue that are produced by cigarette smoking. "The existing data show...
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Genetic Cause Identified in Acinic Cell Carcinoma

​ For the first time, researchers have gained insight into the molecular causes of acinic cell carcinoma, the third most common salivary gland cancer. "Our research means that we can now diagnose acinic cell carcinomas in the salivary glands more easily and understand the fundamental biological processes behind tumor growth. In the long term, we hope that we will also be able to develop new ways of treating patients on the basis of this new research," commented Dr. Florian Haller, Professor in t...
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NSAIDs Increase Survival for PIK3CA-altered Head and Neck Cancer

According to a new study, over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, have been found to significantly increase survival in patients with PIK3CA - altered head and neck squamous cell carcinoma (HNSCC). A mutation in PIK3CA, the gene encoding p110a and the catalytic subunit of phosphoinositide-(3)-kinase a, commonly occurs in HNSCC. In prior research, a sample of 504 patients with HNSCC tumors yielded 174 tumors containing a PIK3CA mutation. In patients with ...
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HPV Vaccine Approval Expanded Through Age 45

​ In a step crucial to preventing the occurrence of both the human papillomavirus (HPV) and HPV-related cancers, the United States Food and Drug Administration (FDA) has expanded the approval of the 9-valent human papillomavirus (9vHPV) vaccine (Gardasil®9, Merck and Co.) for men and women between the ages of 27 and 45. The human papillomavirus infects approximately 14 million Americans each year. It is also a well-documented cause of a number of cancers, including cervical carcinoma and orophar...
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BAP1 Promotes Tumor Suppression Via Ferroptosis

Research performed at The University of Texas MD Anderson Cancer Center shows a potential new area of cancer therapy through the examination of BRCA-associated protein 1 (BAP1), a tumor suppressor gene in kidney, eye, bile duct, mesothelioma, and other cancers. BAP1 encodes a key enzyme which results in a type of cell death called ferroptosis. The team, led by Boyi Gan, PhD, associate professor at the Department of Experimental Radiation Oncology, identified a BAP1-mediated epigenetic mechanism ...
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