Glyphosate-Based Herbicides Linked to Non-Hodgkin Lymphoma

Researchers report that glyphosate, the herbicide commonly found in RoundupĀ® (Monsanto Technology, LLC), which is used as a pesticide on produce, significantly increases the risk of developing non-Hodgkin lymphoma (NHL) in humans. "Our analysis focused on providing the best possible answer to the question of whether or not glyphosate is carcinogenic," remarked the senior author of the paper, Lianne Sheppard, PhD, Professor of Environmental and Occupational Health Sciences and Biostatistics at th...
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Potential Treatment for Relapsed Acute Myeloid Leukemia

Researchers have developed a new treatment that has the potential to work powerfully for some patients with relapsed acute myeloid leukemia (AML). One of the deadliest cancers, AML has a five-year survival rate of around 30%, which drops to under 10% for elderly patients. Around 30% of patients with AML have an activating mutation in the tyrosine kinase domain (TKD) of fms-like tyrosine kinase 3 (FLT3) or an FLT internal tandem duplication. These patients generally respond well initially to...
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Hypodiploid Acute Lymphoblastic Leukemia: Improving Treatment

Around 2% of all pediatric patients with acute lymphoblastic leukemia (ALL) have hypodiploid ALL, a high-risk subtype in which leukemic cells have 25 to 44 chromosomes rather than the standard 46. Researchers have now found important clues that can help alter the poor prognosis for this condition. In a new study published in the Journal of Clinical Oncology , investigators performed a retrospective study of patients with hypodiploid ALL enrolled in research trials for 16 cooperative study groups...
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To Fight Cancer, Grow T Cells in a Lab

Researchers at the University of California, Los Angeles (UCLA) have become the first to successfully develop mature, cancer-killing T cells in a laboratory setting. The immune system's T cells fight infections; they also have the ability to fight cancer. Therapies that involve genetically engineering a patient's own T cells with a receptor that helps the T cells to recognize and destroy cancer cells have tremendous potential for certain types of cancer. One of these therapies is CAR T-cell ther...
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B-Cell Acute Lymphoblastic Leukemia: New Subtypes Found

Although recent genetic research has identified a number of new subtypes of B-cell acute lymphoblastic leukemia (B-ALL), the genetic alterations that initiate many of these subtypes have until now been unknown. In a new study, published in Nature Genetics , researchers have created a revised taxonomy of B-ALL that incorporates 23 subtypes, including 8 new ones, as defined by chromosomal rearrangements, sequence mutations, or heterogeneous genomic alterations. "B-ALL has remarkable molecular dive...
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