Selinexor/Dexamethasone for Triple-Class Refractory Myeloma

A combination of oral selinexor and dexamethasone shows objective responses in patients with multiple myeloma that is refractory to three different classes of currently available therapies, report the investigators of the phase 2b STORM study. ''An increasing number of patients have triple-class refractory myeloma, defined as disease refractory to proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies," write the researchers in their publication in The New England Journal of M...
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Fedratinib Approved for Myelofibrosis

​ The FDA has now approved fedratinib (Inrebic®, Impact Biomedicines, Inc./Celgene Corporation) for the treatment of intermediate-2 or high-risk primary or secondary myelofibrosis. A myeloproliferative neoplasm, myelofibrosis can either present as a primary condition or as a secondary condition following the transformation of polycythemia vera or essential thrombocythemia. Myelofibrosis causes anemia, splenomegaly, and debilitating symptoms, and it shortens survival. "Prior to today, there was o...
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Utilizing Proper Supportive Care in Multiple Myeloma: An Interview With Smith Giri, MD, MHS

​ In the treatment of multiple myeloma, supportive care is essential to mitigating the risks of infection and bone disease. However, a study published recently in Cancer by Smith Giri, MD, MHS, and colleagues found that guideline-recommended supportive care measures are underutilized in older patients with multiple myeloma. In this interview with i3 Health, Dr. Giri discusses supportive care for patients with myeloma, as well as interventions that could increase the use of these measures. Can yo...
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Under Medicare, CAR T-Cell Therapy Now Available Nationwide

The Centers for Medicare & Medicaid Services (CMS) have finalized nationwide coverage of chimeric antigen receptor (CAR) T-cell therapy, replacing the previous policy under which the decision of treatment coverage was left to Medicare's regional administrators. "As the first type of FDA-approved gene therapy, CAR T-cell therapies are an important scientific advancement in this promising new area of medicine and provide treatment options for some patients who had nowhere else to turn," c...
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Older Patients with Myeloma: Supportive Care Underutilized

​ Several facets of supportive care are important in multiple myeloma, including management of bone disease, thromboprophylaxis, and prevention of infectious disease. Appropriate supportive care measures have been outlined in well-established guidelines, but a new study reports that often, these are not followed. For this study, which has been published in Cancer , the researchers focused on three outcomes regarding guideline-recommended supportive care: the use of bone-modifying drugs (BMDs) wi...
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