CAR T-Cell Therapy: New Treatment for Large B-Cell Lymphoma

Large B-cell lymphoma is an extremely destructive, invasive subtype of non-Hodgkin lymphoma. Often, patients with this malignancy have undergone several treatments that have not worked. New therapeutic approaches are necessary for relapsed/refractory disease. A breakthrough personalized treatment, CAR T-cell therapy may be an option for patients with relapsed/refractory large B-cell lymphoma. Patients undergo a process called leukapheresis, in which a patient's blood is collected and put through...
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A Means to Avoid Graft-Versus-Host Disease in Leukemia

Researchers have found a potential way to prevent graft-versus-host disease (GVHD), a serious and sometimes fatal complication of the allogeneic hematopoietic cell transplants used to treat leukemia. Allogeneic hematopoietic cell transplants succeed in fighting leukemia when donated T cells—the immune system's "killer cells," which attack unhealthy cells—attack the cancer cells. Through what is known as graft-versus-leukemia (GVL) activity, these donated T cells work to prevent disease relapse. ...
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How Ribosome Defects Contribute to Leukemia

Ribosomopathies—congenital disorders involving mutations in the structure or function of ribosomal component proteins or their assembly factors—are initially characterized by the underproduction of cells. Yet many ribosomopathies later put individuals at risk for cancers involving the overproliferation of cells. How can this be? "Defects in ribosomes have two different consequences for the cells," explained Kim De Keersmaecker, PhD, Head of the Laboratory for Disease Mechanisms in Cancer in Leuv...
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Healthy Stem Cells Have as Many Mutations as Leukemic Cells

Researchers have found that the quantity of genetic mutations of hematopoietic stem cells (HSCs) in patients with acute myeloid leukemia (AML) is no greater than that of healthy individuals. These mutations are largely generated by normal, age-dependent processes that are constantly active during everyone's life. "We thought that people with leukemia would have more mutations than healthy people, but this is not the case," commented the study's principal investigator, Ruben Van Boxtel, PhD, of t...
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Glasdegib Approved to Treat Acute Myeloid Leukemia

Recently, the FDA approved glasdegib (DaurismoÔ, Pfizer Labs) to be used in combination with low-dose cytarabine (LDAC) for newly diagnosed acute myeloid leukemia (AML) in elderly patients or those ineligible to receive intensive induction chemotherapy. Richard Pazdur, MD, Director of the FDA's Oncology Center of Excellence and Acting Director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research, explained, "Intensive chemotherapy is usually used...
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