3D Imaging Technique Reveals Origins of Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers, with a five-year survival rate of 7%. With early diagnosis, however, that percentage can rise to between 20% and 35%. By developing a new technology to analyze three-dimensional (3D) pancreatic tumor tissue samples, researchers have discovered ways in which the malignancies start and grow. The investigators' new technique can potentially be used for early diagnosis. "To investigate the origins of pancreatic cancer, we spent six years developing ...
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New Targets Identified in BRCA-Mutated Cancers

Researchers at Brigham and Women's Hospital have identified two new genes that can impact BRCA2-deficient cancer through "synthetic lethality," which occurs when a combination of deficiencies in two or more genes leads to cell death that would not occur with one deficiency alone. Inactivation of BRCA1 or BRCA2, both important tumor suppressor genes named for their roles in breast cancer, increases a woman's risk of breast cancer by up to 80% and increases her risk of ovarian cancer by around 50%...
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Pancreatic Cancer Cells Starved by Compound Found in Vine

Researchers from the Institute of Organic Chemistry at the Julius Maximilian University of Würzburgin Germany and the Institute of Natural Medicine of the University of Toyama in Japan have discovered a potential new treatment for pancreatic cancer: a compound called ancistrolikokine E3, which is derived from twigs of the vine Ancistrocladus likoko . Pancreatic cancer is one of the leading causes of cancer deaths, with less than 10% of patients surviving beyond five years. Pancreatic cancer cell...
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Adolescent Weight May Affect Adult Pancreatic Cancer Risk

​ A new study has found a link between obesity during adolescence and increased risk of pancreatic cancer during adulthood. Zohar Levi, MD, of Rabin Medical Center and Tel Aviv University, and colleagues examined Israeli data from 1,087,358 men and 707,212 women who underwent a mandatory physical examination between the ages of 16 and 19 during the years 1967 to 2002. The researchers then used the Israeli National Cancer Registry to identify which of these individuals developed pancreatic c...
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ATRX Linked to Pancreatic Cancer Risk in Women

Results of a study conducted by Lawson Health Research Institute and Western University's Schulich School of Medicine and Dentistry show that mutation of a gene called ATRX is linked to increased risk of pancreatitis and pancreatic cancer in women. Conversely, in men, the mutation is associated with a lowered risk of pancreatic cancer. This discovery marks the first known sex-specific risk factor associated with the disease. The research team evaluated the effects of ATRX mutations in preclinica...
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