PARP Inhibitor Effective in Advanced Pancreatic Cancer

Poly (ADP-ribose) polymerase (PARP) inhibitors, such as rucaparib (Rubraca®, Clovis Oncology), have been shown to be effective for cancers containing BRCA mutations. They have also been successful as maintenance therapy for platinum-sensitive ovarian cancer treated with PARP inhibitors. Therefore, researchers conducted a phase 2 clinical trial to determine if patients with platinum-sensitive advanced pancreatic cancer and a pathogenic germline or somatic BRCA or PALB2 mutation whose cancer had n...
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Targeting KRAS-Driven Pancreatic Cancer

​ The most common form of pancreatic cancer, pancreatic ductal adenocarcinoma is highly difficult to treat, with a five-year survival rate of only 8%. There is one therapeutic target that has led to encouraging preclinical results: inhibition of oncogenic KRAS, a mutation that is present in over 90% of pancreatic ductal adenocarcinomas. However, in mouse models of this disease, genetic extinction of oncogenic Kras has resulted in recurrence that no longer relies on the Kras oncogene. For this re...
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Overprescribing Preventive Drugs to Elderly Patients With Advanced Cancer

Researchers discovered that elderly patients with advanced cancer who continue to take some preventive drugs might not achieve clinical benefit during their remaining lifespan, thereby rendering the drugs unnecessary money and time wasters. In this study, published in Cancer, the investigators found that in 151,201 adults older than 65 with advanced cancer who passed away, patients were prescribed an average of 6.9 to 10.1 drugs over the last year of their life. Preventive drugs, such as antihyp...
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Preventing Metastasis to the Liver

Why is the liver the most common site of metastatic disease? Part of the reason may be that circulating tumor cells are trapped by the liver, which filters the blood coming from the digestive tract before it reaches the rest of the body. That is not the whole story, however. Metastasis to the liver depends on the formation of a "pro-metastatic niche," which creates the conditions that support the spread of tumor cells to the liver.  Until now, little has been known about the mechanisms behi...
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3D Imaging Technique Reveals Origins of Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers, with a five-year survival rate of 7%. With early diagnosis, however, that percentage can rise to between 20% and 35%. By developing a new technology to analyze three-dimensional (3D) pancreatic tumor tissue samples, researchers have discovered ways in which the malignancies start and grow. The investigators' new technique can potentially be used for early diagnosis. "To investigate the origins of pancreatic cancer, we spent six years developing ...
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