In High-Risk Neuroblastoma, Tandem Transplant Is Superior

A randomized clinical trial reports that in patients with neuroblastoma, tandem autologous stem cell transplant improves outcomes compared with single transplant. Neuroblastoma, a malignancy of the developing sympathetic nervous system, is responsible for around 10% to 12% of childhood cancer deaths. For the 43% of patients who present with high-risk disease, which involves either widespread metastasis in patients over the age of 18 months and/or amplification of the MYCN oncogene, the standard ...
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Analysis Reveals Substantial Childhood Cancer Burden

As technology and health care progress, the rate of children who survive five years after being diagnosed with cancer is 80%; however, this rate only applies to children who live in high-income countries (HICs). Those children that live in low-income and middle-income countries (LMICs) make up more than 90% of children who are at risk of developing cancer, and, unfortunately, children who live in LMICs lack the resources necessary to combat childhood cancer compared with children who live in HIC...
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JMJD6 Identified as a Neuroblastoma Tumorigenic Factor

Researchers have identified the JMJD6 gene as a critical factor for neuroblastoma tumorigenesis, indicating potential for a new targeted drug therapy treatment strategy. The most prevalent solid tumor in early childhood cancers, neuroblastoma comprises 15% of total childhood cancer deaths. Neuroblastoma is distinctive from adult cancers in that it is characterized by frequent chromosome copy number variations, and its most prominent features are gene deletion, amplification, or gain. While chrom...
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Birth Defects and Pediatric Cancer: An Interview With Philip J. Lupo, PhD, MPH

​ In their recently published study, Philip J. Lupo, PhD, MPH, and colleagues found that both chromosomal anomalies and nonchromosomal birth defects significantly increase a child's risk of receiving a cancer diagnosis before his or her 18th birthday. In this interview with i3 Health, Dr. Lupo discusses his findings and the future directions of this research. Can you comment on the significance of your results concerning the link between birth defects and pediatric cancer risk? Philip J. Lupo, P...
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Pediatric Brain Tumors: Cognitive Effects in Adulthood

Children with central nervous system (CNS) tumors have good prognoses; 75% will live at least five years after diagnosis. Unfortunately, a recent study has shown that these survivors experience neuropsychological problems and lower socioeconomic status later in life compared with their healthy peers. For this study, published in Cancer, the researchers analyzed data on 181 adult survivors of pediatric low-grade gliomas from the Childhood Cancer Survivor Study and compared them with a group of 10...
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