Vitamin A Reduces Risk of Skin Cancer

According to a recent study, an increased consumption of vitamin A is associated with a decreased risk of squamous cell carcinoma. The second most common form of skin cancer, squamous cell carcinoma arises when an uncontrolled growth occurs in the outermost layer of the skin, called the epidermis. Sun exposure is a huge risk factor of squamous cell carcinoma. This cancer appears as persistent, thick, rough, scaly patches that can bleed. For this study, published in Journal of the American Medica...
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Nivolumab: Five-Year Survival for Melanoma, RCC, and NSCLC

​Five-year overall survival results have now been revealed for nivolumab in advanced melanoma, renal cell carcinoma (RCC), and non-small cell lung cancer (NSCLC)."We report, to our knowledge, the longest combined clinical follow-up for patients with multiple cancer types receiving any anti–PD-L1 drug," the researchers comment in their secondary analysis of data from the phase I CA209-003 trial and expansion cohorts. This trial was the first multidose trial of nivolumab, an immunotherapy drug tha...
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Fat Cells Help Melanoma Cells Metastasize

According to a new study, published in Science Signaling, fat cells play a role in transforming local melanoma cells in the epidermis to metastatic melanoma cells that migrate to attack different organs."We have answered a major question that has preoccupied scientists for years," stated lead study author, Carmit Levy, MD, PhD, and Professor at Tel Aviv University. "What makes melanoma change form, turning aggressive and violent? Locked in the skin's outer layer, the epidermis, melanoma is very ...
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Can Metabolic Regulators Fight Metastatic Melanoma?

Vemurafenib, an inhibitor of mitogen-activated protein kinase signaling downstream of BRAFV600E, can be successfully used to treat patients with metastatic melanoma. However, it produces a high incidence of therapeutic resistance. New strategies are needed to treat vemurafenib-resistant melanoma, so researchers used two bioactive compound libraries and identified two possible targets: deguelin and rotenone."Breakthroughs in understanding the molecular basis for the disease have led to a couple o...
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Synthesizing a Marine Sponge Compound that Fights Cancer

Halichondrins, natural products isolated from marine sponges, have demonstrated antitumor activity both in live mice and in human cancer cell cultures. Previously, the limited supply of halichondrins has made it difficult to develop drugs utilizing their antitumor activity. However, after 30 years of research, scientists have now been able to harvest the tumor-fighting capabilities of halichondrins by incorporating a synthesized version into a drug called E7130.When halichondrins were first disc...
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