Therapeutic Target Identified in Chemo Brain

Chemotherapy is a life-saving treatment for many patients with cancer. However, it can also leave patients with lasting neurological deficits through a condition commonly known as "chemo brain." "It's wonderful that they're alive, but their quality of life is really suffering," commented Erin Gibson, PhD, a postdoctoral researcher at the Stanford University School of Medicine. "If we can do anything to improve that, there is a huge population that could benefit." In a study published in Cell , D...
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Cancer Treatment or Hospice Care—Why Choose?

Unfortunately, Medicare patients have to make the choice between receiving cancer treatment or hospice care; they cannot have both due to cost constraints. However, through the Veterans Health Administration (VHA), cancer treatment and hospice care can occur simultaneously if a patient opts for both. This concurrent treatment can be very valuable to patients and their loved ones; it is important to have the option to receive both treatments at once. "Often, Medicare patients with terminal cancer...
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Novel Management Strategies for Immune-Related Pruritus: An Interview With Shawn Kwatra, MD

Immunotherapies such as PD-1 inhibitors have improved survival for many patients with cancer. However, these therapies are associated with adverse events that, if not properly managed, impair quality of life and may lead to treatment interruptions or discontinuation. Pruritus is one of the most common immune-related adverse events, and while many cases may be managed with conventional therapy, some patients do not respond. Shawn Kwatra, MD and colleagues reported on a case of an 88-year-old woman receiving pembrolizumab, a PD-1 inhibitor, for metastatic lung adenocarcinoma who developed severe pruritus refractory to standard treatment. Dr. Kwatra and colleagues found that intravenous naloxone, an opioid antagonist, resulted in a reduction in pruritus severity from 10 to 1 (on a scale of 0 to 10) within 1 hour. i3 Health spoke with Dr. Kwatra, Assistant Professor of Dermatology at Johns Hopkins University School of Medicine, about his findings and the challenges, potential advances, and role of multidisciplinary care in the management of dermatologic immune-related adverse events.

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​Why We Need Certified Oncology Nurses: An Interview With Barbara Gobel, MS, RN, AOCN®, FAAN

For oncology nurses, certification has a significant impact on career advancement and quality care. Since oncology is a rapidly changing field, up-to-date study materials are therefore crucial. To this end, Oncology Nursing Review, Sixth Edition, has just been published. This new edition is an essential guide for oncology nurses studying for the Oncology Certified Nurse (OCN®) exam offered by the Oncology Nursing Certification Corporation (ONCC). Coauthor Barbara Holmes Gobel, MS, RN, AOCN®, FAAN spoke with i3 Health about the increasing demand for oncology nurses, their role in patient care, and the importance of maintaining certification. 

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Preventing Premature Menopause in Breast Cancer Chemotherapy

Chemotherapy can cure early-stage breast cancer, but it can also result in premature menopause, a highly unwelcome long-term side effect. In the final results of its investigation, the Southwest Oncology Group (SWOG)'s Prevention of Early Menopause Study (POEMS) reports a potential solution: women who receive goserelin (Zoladex®, AstraZeneca) along with standard chemotherapy for hormone-receptor negative breast cancer increase their chances of becoming pregnant without negatively impacting ...
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