What is the Frequency of Opioid Abuse in Cancer Patients?

With the opioid crisis claiming so many lives, physicians need to be especially careful prescribing these drugs. However, for many patients with cancer who are in a lot of pain, opioids can be a necessary part of treatment. So how can physicians determine predictors and frequency of opioid abuse in this population? A study now published in JAMA Oncology found that marital status, higher levels of pain, high scores on the Screener and Opioid Assessment for Patients with Pain (SOAPP), and morphine...
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How Delaying Cancer Treatment Impacts Survival: Eugene Cone, MD

In a study published this past week in JAMA Network Open, Eugene Cone, MD, and colleagues found that a longer time to treatment initiation negatively impacts survival in patients with breast, prostate, colon, and lung cancers, a finding that is particularly relevant with the deferral of treatment during the COVID-19 pandemic. In this interview, Dr. Cone, a clinical fellow in surgery at Massachusetts General Hospital, speaks with i3 Health about the significance of these results and shares advice...
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Time to Treatment Initiation Impacts Survival in Common Cancers

In patients with common cancers, a longer time to treatment initiation is associated with higher all-cause mortality, according to results of a cohort study now published in JAMA Network Open. "The COVID-19 pandemic has forced many hospitals in the US to grapple with decisions on how best to optimize allocation of limited health care resources," write the investigators, led by Eugene B. Cone, MD, of the Division of Urological Surgery at Brigham and Women's Hospital. "Postponing particular cancer...
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Esophageal-Sparing Radiotherapy Reduces Toxicity in Non-Small Cell Lung Cancer

In patients with advanced non-small cell lung cancer (NSCLC), esophageal-sparing intensity-modulated radiotherapy (ES-IMRT) decreased the incidence of treatment-related esophagitis and demonstrated a trend toward improved esophageal quality of life compared with standard radiotherapy (RT), according to results recently presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting. While commonly used to alleviate local symptoms in patients with advanced NSCLC, palliative thorac...
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Antifungal Prophylaxis for Hematologic Malignancies: Yuan Wan, MD, PhD

While antifungal prophylaxis can effectively prevent invasive fungal infections in patients with hematologic diseases, there is no consensus on which prophylactic agents provide the greatest benefit for different patient populations. In a meta-analysis recently published in JAMA Network Open, a team of researchers found that among antifungal prophylactic agents, posaconazole may be the best option for patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS), while voriconazo...
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