Are Cell Lines the Best Model to Analyze Breast Cancer Biology?

Cell lines—a cell culture developed in a lab from a single cell causing all cells to have the same genetic makeup—are a popular tool to analyze breast cancer biology and test drug candidates. However, sometimes a drug that shows promising preclinical performance fails when used in the clinic. To further the understanding of cell line biology compared with tumors, researchers have begun analyzing large volumes of data, called big data, consisting of genomic data from cell lines and tumors. The an...
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