How Does Cancer Treatment Affect Immune Health in HIV Patients?

In people with HIV and cancer, antiretroviral therapy is often used during cancer treatment to mitigate complications of HIV progression. However, questions regarding long-term effects of cancer treatment in this patient population remain, such as the immunosuppressive effects on HIV RNA level and CD4 count, which are indicators of a patient's morbidity and mortality. Therefore, scientists sought to measure the link between these biomarkers and associated mortality after cancer treatment. They p...
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Prostate Cancer: Stereotactic Body Radiotherapy Safely Shortens Treatment

​A phase 3 trial reports that stereotactic body radiotherapy (SBRT), which takes significantly less time than standard-of-care intensity-modulated fractionated radiotherapy (IMRT), is equally safe for patients with prostate cancer.The international, open-label PACE-B trial (NCT01584258) randomized 874 men with low- or intermediate-risk prostate adenocarcinoma in a 1:1 ratio to receive either SBRT (36.25 Gy) in five fractions over one to two weeks, or conventionally fractionated or moderately hyp...
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How Being Unmarried Impacts Cancer Treatment: An Interview With Joan DelFattore, PhD, MS

Studies have shown that unmarried patients with cancer are less likely to receive surgery and radiotherapy than their married counterparts; they are also less likely to survive their cancer. In a research-based perspective essay published in The New England Journal of Medicine, Joan DelFattore, PhD, MS, a survivor of stage IV gallbladder cancer, suggests that contrary to assumptions made by a number of researchers, the disparities in cancer treatment for individuals who are single may stem not f...
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Proton Beam Radiotherapy for Breast Cancer

A phase 2 trial reports that in patients with nonmetastatic breast cancer requiring postoperative radiation therapy, proton beam radiotherapy has low toxicity, with efficacy comparable to that of conventional radiotherapy.A specialized type of external beam radiation, proton beam radiotherapy precisely targets a tumor with high doses of radiation to kill cancerous cells while minimizing damage to nearby tissue and critical organs such as the heart and lungs. For this safety and efficacy study, c...
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Endometrial Cancer: Chemoradiotherapy Versus Chemo Alone

​Because endometrial carcinoma is a heterogeneous disease, it is often difficult to treat, and women diagnosed with advanced disease are at risk for local and systemic recurrence. When researchers tested platinum-based chemotherapy plus radiation therapy against chemotherapy alone in patients with stage III or IVA endometrial carcinoma to see which treatment improved outcomes the most, they discovered that chemoradiotherapy did not improve outcomes more so than chemotherapy alone.This study, res...
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